His work was mainly inspired by the human figure, and a combination of naturalism and expressionism. From the 1960s onward, Mytaras moved in the direction of naturalism, while from 1975 an expressionistic approach became more and more marked in his output. Τhe main characteristic of Dimitris Mytaras’ painting is the coexistence of contradictory elements.Poetry is expressed alongside violence, lyricism with brutality, pleasure with coarseness
From 1953 till 1957, Mytaras studied at the Athens School of Fine Arts with Giannis Moralis. Later on he studied stage design at the Ecole Nationale Superieure des Arts Decoratifs in Paris. From 1964 till 1972, he directed the Interior Decoration Workshop of the Athens Technological Institute. Beginning in 1975, he taught at the Painting Workshop of the Athens School of Fine Arts. Mytaras participated in more than 30 international group shows, including the 1972 Venice Biennale. During the time of the Greek military junta of 1967-1974, Mytaras sought to comment critically on Greek life through a series of realistic works entitled Photographic Documents. Later he turned towards classical themes. For the 2004 Summer Olympics in Athens Mytaras was elected to create a contribution to the official poster.
His works are in all mayor Greek museums and collections as well as in different public and private collections abroad.